Whenever possible, the USAN Council will assign substances to existing stems or nomenclature schemes that describe the substance, or the substance's action or use. A new stem will be created only in the unusual circumstances where existing stems and nomenclature schemes do not accurately represent a compound, or the compound's action, structure or use, and also when substantial clinical and preclinical data support the creation of a new stem.

The following listing of new stems was approved by the USAN Council at the July 11, 2008 USAN Council meeting:

New stems

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